Locus coeruleus - nigral pigmentation and Alzheimer's disease pathology Lead Investigator: Heidi Jacobs Institution : Massachusetts General Hospital E-Mail : hjacobs@mgh.harvard.edu Proposal ID : 1429 Proposal Description: Our aims are: 1. To compare the severity of locus coeruleus and substantia nigra pigmentation across Braak/Thal stages 2. To evaluate the relationship between locus coeruleus and substantia nigra pigmentation with cognitive decline